Respiration is under both nervous and chemical regulation.
The respiratory centre in brain is composed of groups of neurons located in the medulla oblongata and pons varolii. The respiratory centre regulates the rate and depth of the breathing.
Dorsal respiratory group of neurons are located in the dorsal portion of the medulla oblongata. This group of neurons mainly causes inspiration.
Ventral group of neurons are located in the ventrolateral part of the medulla oblongata. These can cause either inspiration or expiration.
The Pneumotaxic centre is located in the dorsal part of pons varolii. It sends signals to all the neurons of the dorsal respiratory group and only to inspiratory neurons of ventral respiratory group. Its job is primarily to limit inspiration. Chemically, respiration is regulated by the large numbers of chemoreceptors located in the carotid bodies and in the aortic bodies. Excess carbon dioxide or hydrogen ions mainly stimulate the respiratory centre of the brain and increase the inspiratory and expiratory-signals to the respiratory muscles. Increased C02 lowers the pH resulting in acidosis. The role of oxygen in the regulation of respiratory rhythm is quite insignificant.